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  • 15th Century B.C. The earliest written reference in the Chinese Pharmacopeia.
  • 1839:  First modern description of cannabis’s pharmacological properties provided by William O’Shaughnessy an Irish physician.
  • 1854:  First listed in the United States Dispensary.  It was promoted for a variety of conditions including sedative, anti-inflammatory, antispasmodic, anticonvulsant and anti-asthmatic.
  • Between 1840 and 1900, more than 100 articles on the therapeutic use of Cannabis were published in medical journals.
  • 1930’s: United States began condemning the use of cannabis
  • 1937: The Marihuana Tax Act of 1937 introduced the first federal restrictions on cannabis.  Required individuals to register and pay tax on cannabis use.  Paper work was also imposed on physicians by the Federal Bureau of Narcotics led to decline in the use.  At the time AMA, was one of the only groups opposed to passing of the tax act.
  • 1942:  Cannabis was removed from United States Dispensary
  • 1964: THC was identified as the primary psychoactive compound and was was successfully synthesized.
  • 1960s:  Resurgance of cannabis use focused on high THC strains
  • 1970:  Passage of the Comprehensive Drug Abuse Prevention and Control naming cannabis sativa as a schedule 1 drug.
  • 1971: Removed from the British Pharmacopoeia
  • 1990s:  CB1 and CB2 receptors identified.
  • 2004 FDA issues a Guidance for Industry Botanical Drug Products
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